Mode of Ligand Binding

Apart from the hydrogen bond potential at the bottom of the pTyr pocket, the phenol ring of pTyr makes a number of hydrophobic contacts with the SH2 

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Is there a unique mode of ligand binding to cholinergic receptors or do multiple modes exist ... 

When an appropriate chiral phosphine ligand and proper reaction conditions are chosen, high enantioselectivity is achievable. If a diphosphine ligand with C2 symmetry is used, two diastereomers for the enamide-coordinated complex can be formed because the olefin can interact with the metal from either the Re- or Sf-face. Therefore, enantioselectivity is determined by the relative concentrations and reactivities of the diastereomeric substrate-Rh complexes. It should be mentioned that in most cases it is not the preferred mode of initial binding of the prochiral olefinic substrate to the catalyst that dictates the final stereoselectivity of these catalyst systems. The determining factor is the differ-... 

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