Mn-porphyrin catalytic response

Students in a chemometrics course performed a fractional factorial design to investigate how the catalytic response of MnM2-BrPTTP 

Mn-porphyrin is affected by seven factors. The results obtained are in Table 4A.4. The response is the ratio between the amount of cyclohexanol produced in the porphyrin-catalyzed reaction and a fixed quantity of an internal standard previously added to the reaction medium. 

Two factors, time (3) and the presence of imidazole (6), do not seem to be important, which transforms the design into a fraction. Of the remaining five factors, two — the catalyst concentration and the cj)IO/MnP ratio — act in the direction of increasing cyclohexanol content, while the other three (stirring method, solvent nature and especially the temperature) tend to decrease it. Fig. 4A.6 shows how the two apparently most important factors affect the response. Should we suspect a possible interaction between them Which of the other three important factors (4, 5 and 7) could you associate with the difference between the response 

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