Mixing of Pharmaceuticals

The extent of homogeneous mixing of pharmaceutical components such as active drug and excipients has been studied by near-IR spectroscopy. In an application note from NIRSystems, Inc. [47], principal component analysis and spectral matching techniques were used to develop a near-IR technique/algorithm for determination of an optimal mixture based upon spectral comparison with a standard mixture. One advantage of this technique is the use of second-derivative spectroscopy techniques to remove any slight baseline differences due to particle size variations. 

WEC conducted at Pfizer in accordance with the ECVAM WEC. A mix of Brown compounds and proprietary agents were used.41 The zebrafish assay by Danlo Ltd. with a mix of pharmaceutical agents and the Brown compounds using an undisclosed proprietary prediction model.38... 

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