Mixed dead-end and product

Substrate Inhibition and Mixed Dead-End and Product Inhibition... 

Although the basis of product inhibition is somewhat different from that of dead-end inhibition, the end results may nevertheless be categorised in the same way, depending upon whether the inhibitor affects the slopes, the intereepts or both in plots of e/v against 1/[S]. Thus the terms competitive, non-competitive, uncompetitive and mixed still apply. If we consider Eqn. 17, a slope effect will be seen, with A as the varied substrate, if the inhibitor affects the term, the both ... 

Figure 9 shows the graphical presentation of Eq. (1134), a plot of i/Uo versus 1/5, in the presence of increasing concentrations of P. The double reciprocal plot has an unusual appearance. Thus, the mixed product and dead-end inhibition by P can be distinguished from the normal product inhibition by P from the fact that the family of straight lines does not intersect at a common point. 

Figure 9. Mixed product and dead-end inhibition in an Ordered Bi Bi system. P reacts with EA as well as with EQ (Scheme (11.31)). The plot of i/un versus l/B is slope-parabolic, intercept-linear.

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