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Mixed and Directed Aldol Reactions

Mixed aldol additions and condensations are those involving two different carbonyl compounds. In the most synthetically useful circumstances, oidy one of the reactants can form an enolate or is more reactive toward nucleophilic addition to its carbonyl group. For example  [Pg.831]

Formaldehyde cannot form an enolate and is so reactive toward nucleophilic addition that it suppresses the self-condensation of the other aldehyde. [Pg.831]

Aromatic aldehydes are another class of carbonyl compounds that cannot form enolates. [Pg.831]

the mixed condensation is favored by both the reluctance of ketones to self-condense and the readiness with which aldol addition is followed by dehydration to give a product in which the double bond is conjugated to both the carbonyl group and an aromatic ring. [Pg.831]

Give the structure of the mixed aidoi condensation product of benzaldehyde with [Pg.831]


See other pages where Mixed and Directed Aldol Reactions is mentioned: [Pg.820]    [Pg.831]    [Pg.831]   


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Direct aldol reaction

Direct mixing

Direct reactions

Directed aldol reaction

Directed reactions

Mixed aldol reaction

Reaction direct reactions

Reaction direction

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