Mix and Match of Tailoring Enzymes

All C9-reduced polyketides first undergo cyclization between Cl and Cl2. The reduced ring is unable to aromatize in the absence of additional enzymes, as seen in the structures of mutactin, RM20b and RM20c. Introduction of chain-length-specific 

Selected Nonacetate Primed Polyketides (R primer unit, -CH2CH2CH3) 

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