Mitochondrial encephalomyopathy, lactic acidosis and strokelike episodes

MELAS, Mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes CPEO, chronic progressive external ophthalmoplegia LHON, Leber hereditary optic neuropathy NARP, neurogenic muscle weakness, ataxia, and retinitis pigmentosa NIDDM, non-insulin-dependent diabetes mellitus TER, termination. 

Figure 8-4. The effect of the MELAS mutation on mitochondrial function is to interfere with function of respiratory Complex I or I and IV, leading to increased levels of NADH and thus also of lactate. CoQ, coenzyme Q MELAS, mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes RC, respiratory complex.

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