Phenylbutazone Misoprostol

NSAIDs (nonsteroidal antiinflammatory drugs) Isolated cases of adverse neurological side effects have been seen with naproxen or phenylbutazone given with misoprostol. Misoprostol also increases the abdominal pain and other side effects of diclofenac and indometacin (indomethacin). Paracetamol (acetaminophen) intensifies pain if given with mifepristone and sulprostone used to induce abortion. 

Misoprostol increases the incidence of abdominal pain and diarrhoea when used with diclofenac or indometacin. Isolated cases of neurological adverse effects have been seen with naproxen or phenylbutazone given with misoprostol. However, no important pharmacokinetic interactions seem to occur between aspirin, diclofenac, ibuprofen or indometacin and misoprostol. NSAIDs are reported not to affect the abortive effects of intravaginal misoprostol. 

Jacquemier JM, Lassoued S, Laroche M, Mazi es B. Neurosensory adverse effects after phenylbutazone and misoprostol combined treatment Lancet (19S9) 2,1283. 

Chassagne Ph, Humez C, Gourmelen O, Moore N, Le LoetX, Deshayes P. Neurosensory adverse effects after combined phenylbutazone and misoprostol. BrJ Rheumatol (1991) 30,... 

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