Mismatch between Strategy and Waste Production

There are two statements that abound in organic textbooks, treatises, reviews, or discussions on organic synthesis. One is that convergent plans are more efficient than linear ones. The other is that plans with fewer steps are also more efficient. Both of these statements are generalizations based on a very simplistic mathematical model in which the compared plans have identical reaction yield performances for all steps. This is the only condition that makes them true. Moreover, the 

Summary of Head-to-Head Pairwise Comparisons of Plans Highlighting Mismatches in Kernel Metrics Parameters 

Target Plan Year Type N M / % Yield % AE Waste (kg/mol) -Kernel 

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