Miscellaneous Terpenoids of Clinical Interest

Methysergide or UML 491 (LXXV) has seen limited use in the prophylaxis of migraine [608-622], although it is prone to produce gastro-intestinal upsets, nausea, dizziness and oedema. The reason for the efficacy of this compound. 

With the demonstration [655 a] that 2,3-iminosqualene is an effective inhibitor of 2,3-epoxysqualene cyclase from hog liver microsomes thus preventing cholesterol biosynthesis, it remains to be seen whether this compound or some of ist analogues will find application as antihypercholesterolaemic agents. 

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