Miscellaneous Click Reactions

Displacement of bromine by various thiols by Sjj2 nucleophilic substitution is definitely one of the best examples of click reaction. These reactions proceed well even in the presence of other nucleophiles such as alcohols and amines, owing to the increased nucleophilicity of thiols and thiolates. 2-Mercaptoethanol and other aliphatic thiol-dialcohol molecules when added to polymers, end-functionalized by halogen atoms, result in selective thiol end-functionalization of polymer chains. 

Other than the click reactions mentioned earlier, there are few others that can be 

Applications of Click Chemistry in Drug Discovery and Development 

Part A Application of Click Chemistry to Drug Discovery and Development 

Click Reactions in Organic Synthesis, First Edition. Edited by Srinivasan Chandrasekaran. 

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