Miscellaneous Affinity Labels

The application of site-specific modification of enzymes and other proteins has become increasingly common, and a wide range of chemical classes is available from which to select or design a reagent for exploring a particular enzyme. Structural similarity to the natural ligand is always desirable to ensure target sped- 

This work was supported by U.S. Public Health Service Grants DK 37000 and DK 39075 and by National Science Foundation Grant DMB-88-04706. 

(1976). Design of Active Site-Directed Irreversible Enzyme Inhibitors. Wiley, New York. 

Bazaes, S. (1987). In Chemical Modification of Enzymes (J. Eyzaguirre, ed.), Chap. 3, p. 35. Horwood, Chichester, England. 

and Bell, E. T. (1988). In Proteins and Enzymes, Chap. 8, p. 184. Prentice-Hall, Englewood Cliffs, New Jersey. 

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