MIPs as the Stationary Phase for Analytical Racemic Separations

2 MIPS as the Stationary Phase for Analytical Racemic Separations 

The economic interest is very important in the development of the drugs. The separation methods are more economical than the asymmetric synthetic methods, and hence the development of rapid, reproducible, and inexpensive resolution methods is a demanding area. Conventionally, enantiomeric separation is performed by fractional crystallization, microbiological methods, kinetic enzymatic resolution, or by chromatographies [Ilisz et al., 2006), which have the problems of robustness, reproducibility, ease, and cost effectiveness. 

MIP-based enantiomeric separation is attractive due to their high enantioselectivity and stability. When an enantiomer is used as the template, then the resulting MIP can show capability of enantiomeric recognition between the pair of enantiomers. 

The reviews provide a more comprehensive coverage on topic [Ansell, 2005 Jo et al, 2013). The recent applications in the area are presented in the Table 18.3. 

L-tryptophan Anodic stripping cyclic voltammetry and chronocoulometry. Prasad et al. 2011 

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