Minocycline thyroid gland

Whatever the mechanism may be, the high incidence of associated papillary thyroid cancer mandates at a minimum that one ask about the use of minocycline in any patient who has an enlarged thyroid. The authors recommended that if a patient has taken minocycline in the past, biopsy and possibly removal of the thyroid gland is advisable. 

Birkedal C, Tapscott WJ, Giadrosich K, Spence RK, Sperling D. Minocycline-induced black thyroid gland medical curiosity or a marker for papillary cancer Curr Surg 2001 58 471-1. 

Endocrine Black discoloration of the thyroid gland occurred in a 31-year-old woman who had taken minocycline for 18 months before presenting with hyperthyroidism and a palpable thyroid nodule a concurrent papillary microcarcinoma was probably coincidental [135 ]. 

Taurog A, Dorris ML, Doerge DR. Minocycline and the thyroid antithyroid effects of the drug, and the role of thyroid peroxidase in minocycline-induced black pigmentation of the gland. 

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