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Minocycline MMPs

Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong VW (2002) Targedng leukocyte MMPs and dansmigradon minocycline as a potendal dierapy for muldple sclerosis. Brain 125 1297—1308. [Pg.655]

Observational studies Tetracyclines, especially minocycline, inhibit the matrix metal-loproteinases (MMPs), and this has been studied in patients with the so-called fragile X syndrome (MIM 300624), an inherited form of intellectual disability and autism, with an estimated prevalence of about 1 in 4000 [125. The gene responsible is located on the X chromosome (Xq27.3) and is called Fragile X Mental Retardation-1 (FMRl MIM 309550) [126 ]. Minocycline improved behavioral performance and reduced anxiety in a FMRI knockout mouse [127 ], and has been studied in an open trial in 20 patients with the fragile X syndrome, aged 13-32 years [128 ]. The... [Pg.499]

See other pages where Minocycline MMPs is mentioned: [Pg.87]    [Pg.87]    [Pg.3331]    [Pg.3333]    [Pg.165]    [Pg.166]    [Pg.231]    [Pg.499]   
See also in sourсe #XX -- [ Pg.499 ]



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MMPs

Minocycline

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