Minimization of Flux Decline With Backpulse or Backwash

1 Minimization of Flux Decline With Backpulse or Backwash 

Almost all cross-flow filtration processes are inherently susceptible to flux decline due to membrane fouling (a time-dependent phenomenon) and concentration polarization effects which reflect concentration buildup on the membrane surface. This means lower flux (i.e., product output) which could drive the capital costs higher due to the requirement of a larger surface area to realize the desired production rate. In some situations, the lower flux could also result in lower selectivity which means reduced recoveries and/or incomplete removal of impurities from the filtrate. For example, removal of inhibitory metabolites such as lactic acid bacterial or separation of cells from broth while maximizing recovery of soluble products. 1 1 

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