Mineralized Versus Nonmineralized Tissues

It is intriguing to try to analyze if differences in mechanochemical transduction mechanisms could explain why some tissues mineralize normally and others do not. This would make it possible to attempt to analyze why heart valves and vessel walls mineralize abnormally in diseases leading to valvular failure or cardiac insufficiency. 

4 Cell Cytoskeleton, Extracellular Matrix, and Mechanochemical Tranduction 

It is clear from these studies that external mechanical loading not only affects the cellular response through changes in genetic expression by cells, but it also sets into motion a cascade of events that balances cellular biochemical and biomechanical responses with changes in the environmental 

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