Mimics biological activity

In the future hybrid materials made from selected polyelectrolyte species and silica will be applied to mimic biologically active surfaces by manipulation of their biological activity and compatibility or they will be used as support for enzyme catalysis (Scheme 1). 

Many efforts have been made to find optimal synthetic routes of a-methylene carbonyl compounds. These simple but interesting molecules are used in a variety of applications, such as synthetic intermediates 14], to mimic biologically active natural products [15] and as potential antitumor drugs [16]. 

Fig. 19. The sulfated glycoprotein mimics were tested for biological activity against the se-lectin family of proteins, which are involved in the inflammatory response. These results suggest that length may be a factor in the selectivity of polymers for different proteins...

Thioxotetrahydro-l,3-0,iV-lieterocycles are commonly named cyclic thiocarbamates or thionocarbamates. The structural association of five- and six-membered thionocarbamates with diverse carbohydrate scaffolds has shown a promising potential in modern organic synthesis and in the preparation of biomolecules mimics. The principal pathways for their synthesis, the recent and most important developments of their chemical transformations as well as some examples of their biological activities will be considered in the following discussion. 

Biological activity May mimic naturally occurring molecules Primary mechanism of toxicity Predictive based on mechanism Less predictive... 

Unlike the small molecule drugs (pharmaceuticals) described in Chapter 3, large molecule drugs (biopharmaceuticals) are mainly protein based. Another distinction is that these protein-based drugs are, in the main, similar to natural biological compounds found in the human body or they are fragments that mimic the active part of natural compounds. 

While the naturally-occurring molecules of Part VI were being investigated, synthetic compounds with complex-forming properties had been obtained by Pedersen, and their biological activities studied and found, in some cases, to mimic the behaviour of the neutral macrocydic antibiotics. These synthetic compounds are attractive as models because the... 

Asano, N., Nash, R. J., Molyneux, R. J., Fleet, G. W. J. (2000). Sugar-mimic glycosidase inhibitors natural occurrence, biological activity and prospects for therapeutic application. Tetrahedron-Asymmetry, 11, 1645-1680. 

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