Mimic effects

Follitropin alfa Activates FSH receptors Mimics effects of endogenous FSH Controlled ovulation hyperstimulation in women infertility due to hypogonadism in men SC injection 3-7 x/wk Toxicity Ovarian hyperstimulation syndrome and multiple pregnancies in women gynecomastia in men headache, depression, edema in both sexes... 

Fig. 15. Effects of small-amplitude reorientation on 2H NMR stimulated-echo experiments, as calculated by means of RW simulations. The C-2H bonds perform rotational random jumps on the surface of a cone with a full opening angle % = 6°, which are governed by a broad logarithmic Gaussian distribution of correlation times G(lgr) (a = 2.3). (a) Correlation functions m tp — 30 is) for the indicated mean logarithmic time constants lgr 1. The calculated data are damped by an exponential decay, exp[—(tm/rso)] with rSD = 1 s, so as to mimic effects due to spin diffusion. The dotted lines are fits with Fcos(tm tp) = (1—C) expHtm/t/l + Qexp[—Om/rso)]- (b) Amplitude of the decays, 1-C,p, for various t resulting from these fits. The dotted line is the value of the integral in Eq. (12) as a function of rm. (Adapted from Ref. 76).

D.L. Jiang, T. Aida, A Dendritic Iron Porphyrin as a Novel Haemoprotein Mimic Effects of the Dendrimer Cage on Dioxygen-Binding Activity , Chem. Commun., 1523-1524 (1996)... 

The results of these studies and others reported previously demonstrate that the 1-oxypyridinyl group is an effective catalyst for the transacylation reactions of derivatives of carboxylic and phosphoric acids when incorporated in small molecules and polymers. Furthermore, this catalytic site exhibits high selectivity for acid chlorides in the presence of acid anhydrides, amides, and esters. Therefore, catalysts bearing this group as the catalytic site can be used successfully in synthetic applications that require such specificity. The results of this work suggest that functionalized polysiloxanes should be excellent candidates as catalysts for a wide variety of chemical reactions, because they combine the unique collection of chemical, physical, and dynamic-mechanical properties of siloxanes with the chemical properties of the functional group. Finally, functionalized siloxanes appear to mimic effectively enzyme-lipophilic substrate associations that contribute to the widely acknowledged selectivity and efficiency observed in enzymic catalysis. 

A key role played by chemists is learning how to mimic effectively nature s bountiful manufacturing processes. Once in a while, such a strategy—when it pans out—can tell a story of research-to-riches. Robert Holton, an... 

Peptidylphosphonates have been demonstrated to mimic effectively the transition state involved in the enzymatic hydrolysis of the peptide bond, and are commonly used as inhibitors of peptidases, and in particular of metallo-proteases [146], A solid-phase method for the introduction of the (/[P0(0Me)0] motif exploits a modified Mitsunobu reaction (Scheme 7.11) [147]. 

In Vitro Model to Mimic Effects Seen in Humans.759... 

A/WTRO MODEL TO MIMIC EFFECTS SEEN IN HUMANS... 

R. Breslow, C. Schmuck, Goodness of ht in complexes between substrates and ribonuclease mimics effects on binding, catalytic rate constants, and regiochemistry, J. Am. Chem. Soc., 1996, 118, 6601-6605. 

As we have seen, X-ray studies of the ionophorous antibiotics and their cation complexes were able to explain many of the steric factors that determine the selectivity patterns shown by these ligands. However, more systematic investigations on the relationship between host-cavity size and guest-ion radius could only be carried out using simpler synthetic ligands as models. In 1967, Pedersen reported the synthesis and complexing properties of a new class of compounds named crown ethers which are able to mimic effectively their natural counterpieces. 

Jiang, D.-L. and Aida, T. (1996) A dendritic iron porphyrin as a novel haemoprotein mimic Effects of the dendrimer cage on dioxygen binding affinity, Chem. Commun. 1523-1524. 

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