MIMETIC-GEMO

We have developed a computer program MIMETIC-GEMO, the purpose of which is to be of some help in answering points 1 and 2. 

In MIMETIC-GEMO the molecular energies and deformations are calculated using a previously described computer program (1J, while the minimization is conducted with a standard routine i2J. When the minimum is reached, it is interesting to know for each molecule ... 

The two compounds JLI and III are much more potent (in Rats) than the marketed product I. While it is easy to recognize the common p-chloro-phenoxyacetic ester in all compounds, the origin of the enhanced activities of structures 11 and III is questionable and MIMETIC-GEMO would appear to be useful for finding out whether these two molecules might not have more important features in common. 

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