Serotonin agonists migraine

Sumatriptan is a 5HT (serotonin) agonist indicated in the treatment of migraine. Sumatriptan causes vasoconstriction and must therefore be used with caution in patients with coronary heart disease, such as angina. Concurrent administration of the agonist, sumatriptan and antagonists, such as fluoxetine, which is a selective serotonin re-uptake inhibitor, leads to increased CNS toxicity. 

Qll Sumatriptan is a serotonin agonist (5-HTj agonist) that reduces the cerebral vasodilation which is believed to cause migraine headache. 

The etiology of migraine headaches is currently attributed to the neurovascular hypothesis, with the release of vasoactive neuropeptides and subsequent vasodilation of blood vessels. Serotonin plays an important role in migraine pathophysiology, and serotonin agonists have an important role in migraine treatment. 

Which of the following is a serotonin agonist useful for aborting an acute migraine headache and is not derived from a fungus ... 

Ferrari MD, Roon KI, Lipton RB, Goadsby PJ. Oral triptans (serotonin 5-HT1BAD agonists) in acute migraine treatment A meta-analysis of 53 trials. Lancet 2001 358 1558-1575. 

Sumatriptan (Imitrex) [Antimigraine Agent/Selective 5-HTi Receptor Agonist] Uses Rx acute migraine Action Vascular serotonin receptor agonist Dose Adults. SQ 6 mg SQ as a single dose PRN repeat PRN in 1 h to a max of 12 mg/24 h PO 25 mg, repeat in 2 h, PRN, 100 mg/d max PO dose max 300 mg/d Nasal spray 1 spray into 1 nostril, repeat in 2 h to 40 mg/24 h... 

Mechanism of Action A serotonin receptor agonist that binds selectively to vascular receptors, producing a vasoconstrictive effect on cranial blood vessels. Therapeutic Effect Produces relief of migraine headache. 

Contraindications Basilar or hemiplegic migraine, coronary artery disease, ischemic heart disease (including angina pectoris, history of Ml, silent ischemia, and Prinzmetal s angina), uncontrolled hypertension, use within 24 hours of ergotamine-contain-ing preparations or another serotonin receptor agonist, use within 14 days of MAOls... 

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