Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Mifepristone antagonist

J Medroxyprogesterone j Norgestrel ) Norethindrone Desogestrel I Mifepristone (antagonist)... [Pg.299]

Antiprogestins are progesterone receptor antagonists such as mifepristone (RU 38486), ORG 31710, ZK137 316, ZK 230 211, ZK98299 (Onapristone). [Pg.171]

To date, the results of five phase II clinical trials with PR antagonists in patients with metastatic breast cancer have been reported [191]. In postmenopausal women, two studies with mifepristone as second- or third-hne treatment for metastatic breast cancer showed an objective response rate (complete response plus partial response) of 10 and 13% and stable disease in 54 and 40% of patients, respectively. A third study was conducted using mifepristone as first-line treatment. An objective response rate of 11% and a stable disease rate of 39% was reported [191]. [Pg.63]

The synthesis of the first of these antagonists, mifepristone (28-3), starts by conversion of the intermediate (24-2) to the corresponding 3,17 diketone by sequential saponfication of the benzoate at 17 and oxidation of the resulting alcohol. Reaction of the compound with ethylene glycol proceeds preferentially at the 3 position to... [Pg.137]

Mifepristone, an antagonist at progesterone and glucocorticoid receptors, has a luteolytic effect and is effective as a postcoital contraceptive. When combined with a prostaglandin it is also an effective abortifacient. [Pg.912]

Maria B, Stampf F, Goepp A, Ulmann A. Termination of early pregnancy by a single dose of mifepristone (RU 486), a progesterone antagonist. Eur J Obstet Gynecol Reprod Biol 1988 28(3) 249-55. [Pg.288]

Antiprogestins (eg, mifepristone) have been combined with an oral oxytocic prostaglandin (eg, misoprostol) to produce early abortion. This regimen is now available in the USA (see Chapter 39 Adrenocorticosteroids Adrenocortical Antagonists). The ease of use and the effectiveness of the combination have aroused considerable opposition in some quarters. The major toxicities are cramping pain and diarrhea. [Pg.449]

RU486 (= Mifepristone)] Nobel Prize, Chemistry, 1939, sex hormones, acceptance forbidden by Nazis) Synthetic PROG-R antagonist [early... [Pg.477]

See other pages where Mifepristone antagonist is mentioned: [Pg.285]    [Pg.582]    [Pg.285]    [Pg.582]    [Pg.120]    [Pg.547]    [Pg.531]    [Pg.262]    [Pg.220]    [Pg.256]    [Pg.61]    [Pg.61]    [Pg.62]    [Pg.64]    [Pg.701]    [Pg.253]    [Pg.278]    [Pg.328]    [Pg.461]    [Pg.137]    [Pg.150]    [Pg.889]    [Pg.889]    [Pg.914]    [Pg.225]    [Pg.1253]    [Pg.285]    [Pg.276]    [Pg.309]    [Pg.438]    [Pg.926]    [Pg.927]    [Pg.961]    [Pg.52]    [Pg.160]    [Pg.278]    [Pg.288]    [Pg.254]    [Pg.453]    [Pg.547]    [Pg.207]    [Pg.190]    [Pg.123]   
See also in sourсe #XX -- [ Pg.156 ]



SEARCH



Glucocorticoid receptor antagonist mifepristone

Mifepristone

© 2024 chempedia.info