Midodrine hydrochloride

Sra J, Maglio C, Biehl M, Dhala A, Blanck Z, Deshpande S, Jazayeri MR, Akhtar M. Efficacy of midodrine hydrochloride in neurocardiogenic syncope refractory to standard therapy. J Cardiovasc Electrophysiol 1997 8(l) 42-6. 

Wang Y, Fan Q, Sang Y. Effects of fattj acids and iontophoresis on the delivery of midodrine hydrochloride and the structure of human skin. Pharm Res 2003 20(10) 1612—1618. 

Midodrine hydrochloride is a vasopressor that activates arteriolar and venous a-adrenergic receptors, resulting in an increase in vascular tone and elevation of BP. It is indicated in the treatment of symptomatic orthostatic hypotension in patients whose lives are considerably impaired despite standard clinical care, inclnding snpport stockings, fluid expansion, and lifestyle changes. 

An example of precipitation in the presence of a second solvent is seen in the case of indomethacin. The y-crystal form of indomethacin can be obtained by recrystallization from ethyl ether at room temperature, but the a-form is prepared by dissolution in methanol and precipitation with water at room temperature [33], Precipitation can also result from the addition of a less polar solvent. Form II of midodrine hydrochloride, metastable with respect to Form I, can be prepared by precipitation from a methanolic solution by means of a less polar solvent such as ethyl acetate or dichloromethane [34],... 

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