Valerian Midazolam

A 58-year-old man who had regularly taken excessive doses of valerian root extract for many years was given naloxone postoperatively and developed extreme tremulousness and worsening ventilation. His condition deteriorated and he became delirious. He was treated with midazolam, lorazepam, and finally reducing doses of clonazepam and made an uneventful recovery. 

In rats administered isoflurane alone (5%), isoflurane plus valerian (30 mg/kg), isoflurane plus midazolam (2 mg/ kg), or isoflurane plus valerian (30 mg/kg) and midazolam (2 mg/kg), no significant differences in emergence time from anesthesia were observed in the isoflurane plus valerian... 

---