Microtubule-associated protein 1 light chain

Longhurst, D. M., Watanabe, M., Rothstein, J. D., and Jackson, M. (2006). Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains Link between microtubules, actin cytoskeleton, and neuronal polarity./. Biol. Chem. 281, 12030-12040. 

Ahhreviationy. ATi apoptosis inducing fector, At f5 autophagy protein 5, LC3B microtubule-associated protein 1 light chain 3B, mtHSPJO heat shock protein 70 mitochondrial isoform, p62/SQSTMp62/sequestosome 1 Phalloidin is a toxin isolated from the deadly Amanita phalloides that binds directly F-actin... 

In mammalian cells, autophagosomes initiate from isolation membranes (IMs). IMs expand, enfold cytosol, and finally close, forming autophagosomes. Microtubule-associated protein light chain 3 (LC3, the mammalian homolog... 

Several pathological self-polymerizing systems have been biophysi-cally characterized sufficiently to permit identification of protein or peptide species that could serve as molecular targets in a structure-activity relationship. These include transthyretin (TTR) [73-76], serum amyloid A protein (SAA) [77], microtubule-associated protein tau [78-80], amylin or islet amyloid polypeptide (IAPP) [81,82], IgG light chain amyloidosis (AL) [83-85], polyglutamine diseases [9,86], a-synuclein [47,48] and the Alzheimer s (3 peptide [87-96]. A variety of A(3 peptide assay systems have been established at Parke-Davis to search for inhibitors of fibril formation that could be therapeutically useful [97]. 

Pedrotti B, Ulloa L, Avila J, Islam K. Characterization of microtubule-associated protein MAPIB phosphorylation state, light chains, and binding to microtubules. Biochemistry 1996 35 3016-3023. 

LC3 Microtubule-associated protein 1 (MAPI) light chain 3... 

This enzyme [EC 2.7.1.123], also referred to as calcium/ calmodulin-dependent protein kinase type II, and micro-tubule-associated protein MAP2 kinase, catalyzes the reaction of ATP with a protein to produce ADP and an 0-phosphoprotein. The enzyme requires calcium ions and calmodulin. Proteins that can serve as substrates include vimentin, synapsin, glycogen synthase, the myosin light-chains, and the microtubule-associated tau protein. This enzyme is distinct from myosin light-chain kinase [EC 2.7.1.117], caldesmon kinase [EC 2.7.1.120], and tau-protein kinase [EC 2.7.1.135]. 

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