Microsomal glucose transport protein

Waddell ID, Zomerschoe AG, Voice MW, Burchell A (1992), Cloning and expression of a hepatic microsomal glucose transport protein, Biochem. J. 286 173-177. 

Microsomal glucose transport protein (GLUT ), which is a member of the family of facilitative glucose transport proteins (Chapter 13) and which transports glucose into the cytosol. 

Microsomal phosphate transport protein (T2Q ) which mediates the efflux of P , an inhibitor of the glucose-6-phosphatase, from the lumen of the endoplasmic reticulum to the cytosol ... 

Recently, increasing evidence for a possible glucose-transport-mediating function for small G-proteins has been produced. Such G-proteins are identified in low-density microsomes (Cormont et al., 1991) where most of the GLUT-4 protein is located before stimulation with insulin. 

Microsomal phosphate/pyrophosphate transport protein M.W. 37,000), which transports phosphate, pyrophosphate, and carbamoyl phosphate, which are substrates for glucose-6-phosphatase and... 

Proteins are hydrolyzed to amino acids, which enter the Krebs cycle after transportation in the blood and transamination in the liver. The reversal of the Krebs cycle and the Embden-Meyerhof pathway converts the Krebs cycle substrates into glucose. The conversion of glucose-6-phosphate to glucose is catalyzed by a microsomal enzyme, glucose-6-phosphatase. The mechanisms controlling gluconeogenesis are discussed in more detail in Chapter 16. 

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