Microscopic redox potentials, interaction

The substituent at C-3 of the pyridine ring can serve both as a handle for enzyme binding and as a mediator of the microscopic redox potential. The importance of these interactions for coenzyme function has been probed by inves-... 

Table III. Interaction Potentials from Microscopic Redox Potentials ...

Although complex, the ability to assign microscopic redox potentials and to determine interaction potentials sets the stage for the analysis of the redox data in terms of the structure of cytochrome c3. This approach should greatly expand our understanding of biological redox potentials and facilitate efforts to exploit and understand the electrochemical, electrical, and kinetic properties of cytochrome c3. 

Table 5. Thermodynamic parameters for D. vulgaris cytochrome c3. The diagonal (boldface) numbers represent the microscopic reduction potentials (mV) and the energy for deproto-nating the ionizable redox-Bohr center [meV, (pKa2.3RT)/F)] of the fully reduced molecule. The off-diagonal values give the redox interaction due to individual heme oxidation and protonation of the redox-Bohr center [54]...

Table 6. The estimated microscopic formal redox potentials and interacting potentials of Dv. Miyazaki cytochrome C3 [127]...

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