Micromixer slit interdigital

A microreactor was also applied to this reaction. The slit interdigital micromixer was purchased from IMM (Mainz, Germany). The width of the interdigital channels is 25 pm. HPLC pumps were used to feed the two reaction solutions. One is a mixture of Boc-AMP and 1.2 molar equivalents of r-BocaO. The other is a 50% aqueous KOH solution. The microreactor was immersed in a temperature controlled cooling bath at 15 °C. The product was quenched with an acid, and samples were taken for HPLC analysis. 

Figure 19.5 Construction and mode of operation of the standard slit interdigital micromixer, (a) Left, upper housing with two inlets and the outlet slit in the middle center, inlay with interdigital mixing structure right, lower housing with cutout for the inlay, (b) Mixing principle fluids to be mixed flow into mixing channels, formation of a fluid lamellae and disintegration into droplets [53].

A slit-type interdigital micromixer was used for fast mixing [30] and compared to a tubular reactor and five Kenics mixers connected in series. Details on further components of the micromixer rig were not given, but most likely a capillary reactor was added for efficient heat exchange. 

In interdigital multilamination micromixers, the small thickness of the lamellae leads to short diffusion paths, resulting in fast mixing. Further thinning of the liquid lamellae should lead to shorter diffusion paths and faster mixing. The IMM single mixer applied this concept by shrinking the channel width in the slit. A further extension of this concept leads to the... 

Process development was carried out at laboratory scale using a slit-type interdigital micromixer-reactor [31]. The whole flow guidance was provided by the micromixer and the outcoming solution was collected in a vessel. 

A slit-type interdigital micromixer has been used [34]. Details on the type of plant as well as on the processing were not given. 

An interdigital slit-type high-pressure micromixer followed by a tube (0.9 mm inner diameter 2.6 m long) was used [48]. The micromixer-tube reactor was submersed into a thermostat bath for temperature setting. HPLC pumps fed the monomer and initiator flows. A back-pressure cartridge (70 bar) and a pressure sensor served for pressure control. The temperature was set to 105 °C. The processing protocol was carried out conventionally, using the specs of similar batch processes. 

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