Microgel surface modification

As many other DDS, microgels can be derivatized with receptor-recognizing ligands to enhance the tumor- or specific organ targeting. Surface modification of poly(fV-isopropylacrylamide)... 

Vinyl groups of 1,4-DVB microgels have been converted to carboxylic acid groups by ozone [291]. After modification the microgels could be dissolved in methanol. About 83 % of the vinyl groups could be converted. A simpler way to prepare microgels with carboxyl acid groups at their surface is the copolymerization of DVB with methacrylic acid in an aqueous emulsion [292]. 

In conclusion, DAP resins with improved flexibility were successfully obtained by introducing flexible crosslinked units on the surface of the microgel, i.e., by crosslinking flexibly microgels to form the macrogel. This finding may become a useful guideline for the modification of three-dimensional polymers As an extension of... 

In another modification (425) concentrated ammonia was added as a coacervating agent for the silicate and then the silicate was partly neutralized to pH 10.6-11.2 and precipitated, filtered and washed with acid, washed, dried, and pulverized. In this case, there was no aging or. heating period, which probably explains the high surface area of 449 m g . The particles (probably porous microgel) are 50-75 nm in size and the pore volume 2.4 cm g, which explains the low bulk density of only 0.06 gcm . ... 

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