Microfluidic Same-Single-Cell Analysis

Microfluidk Same-Single-Cell Analysis, Fig. 3 Layout of the microfluidic chip, (a) The schematics of the microfluidic chip consisting of three solution reservoirs and a cell retention structure, with dimensions shown in microns, (b) An image of the microchip filled... [Pg.2011]

The same-single-cell analysis conducted in a microfluidic chip has demonstrated the advantages in identifying MDR modulators and in quantifying the MDR reversal effect of dmg candidates during the dmg efflux stage. A mathematical model based on the Michaelis-Menten... [Pg.2013]

Li X, Ling V, Li PCH (2008) Same-single-cell analysis for the study of drug efflux modulation of multidrug resistant cells using a microfluidic chip. Anal Chem 80(11) 4095 102... [Pg.2014]

Li X, Chen Y, Li PC (2011) A simple and fast microfluidic approach of same-single-cell analysis (SASCA) for the study of multidrug resistance modulation in cancer cells. Lab Chip 11(7) 1378-1384... [Pg.2015]

The glass chip used for the same-single-ceU analysis was fabricated by the standard microfabrication procedure, with the channel depth of 20 pm (Fig. 3) [21]. This microfluidic chip was applied for analysis of human wild-type (WT) T-ceU leukemic cell line CCRF-CEM (CEMAVT, dmg sensitive) and its multidrug-resistant vinblastine-selected subline (CEMA LBO.05) [5, 21]. [Pg.2010]

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