Microfluidic immunosensors

Regiart, M., Ferndndez-Baldo, M.A., Spotorno, V.G. et al. (2013) Ultra sensitive microfluidic immunosensor for determination of clenbuterol in bovine hair samples using electrodeposited gold nanoparticles and magnetic micro particles as bio-affinity platform. Biosens. Bioelectron., 41,211-217. 

Fernandez-Baldo, M.A., Messina, G.A., Sanz, M.I. and Raba, J. (2010) Microfluidic immunosensor with micromagnetic beads coupled to carbon-based screen-printed electrodes (SPCEs) for determination of Botrytis cinerea in tissue of fruits. J. Agric. Food Chem., 5S, 11201-11206. 

The idea followed under this section is to give an overview of the potential of electrochemical microfluidic devices as (bio)-sensor platforms devoted to agricultural and food analysis. Although these types of microdevices have been reported in an important number of published works, those associated to food analysis are very limited [57, 58]. Related to this scope, most of the published works fall within electrochemical microfluidic immunosensors. Relevant examples in food analysis will be given in this section. 

Seia, M.A., Pereira, S.V., Femandez-Baldo, M.A., Vito, I.E.D., Raba, J., Messina, G.A., 2014. Zinc oxide nanoparticles based microfluidic immunosensor applied in congenital hypothyroidism screening. Analytical and Bioanalytical Chemistry 406, 4677-4684. 

Combination of both techniques explodes the selectivity and sensitivity from immunoassays with the remarkable features from microfluidic platforms. Microfluidic immunosensors make use of a network of microchannels and/or immunoreactor chambers usually built in a monolithic platform with part or all the necessary components for immunoassay procedures. 

All these advantages have made microfluidic immunoassays platforms as emergent, powerful option for the analysis of a broad variety of analytes in different fields. Although still it is in its infancy, microfluidic immunosensors reveal as very promising tool in environmental applications. For supplementary information, the reader is guided to excellent review articles. ° ° ... 

Bange A, Halsall HB, Heineman WR (2005) Microfluidic immunosensor systems. Biosens Bioelectron 20 2488-2503... 

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