Microfluidic enzymatic reactors applications

Another application of microfluidic enzymatic reactors is in the enormous and diverse challenges of proteomic investigations. Enzymatic microreactors present proteomics with a valuable analytical tool for protein analysis. Most of applications of IMERs are currently directed at protein analysis by protein digestion and peptide mapping. 

To fulfill such requirements, attempts have been made in the past decade by researchers working on peptide mapping and proteomics through development of immobilized microfluidic enzymatic reactors. Microfluidic enzymatic microreactors are an alternative to in-solution method employing immobilization of proteases on microchaimels of chip-based reactors or surfaces of capillaries. The microreactors that enable proteolytic digestion by enzymes immobilized on solid supports are also referred to as immobilized enzyme reactors, IMERs. The great potential of IMERS for proteomic applications comprise rapid and enhance... 

Many advantages have been reported with the use of microfluidic reactors in biocatalytic reactions. These advantages can potentially enable the rapid evaluation of different reaction conditions, overcoming the time constraints associated with biocatalytic process development. Biocatalysis by enzymatic microreactors have been widely reported. Enzymatic microreactors are classified based on their applications such as microreactors for enzymatic diagnosis and genetic analysis, for enzyme-linked immunoassays, and for analysis of proteins. Microreactors for genetic analysis have been widely exploited, while integration of microfluidics... 

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