Microfluidic Analysis System

S.B. Cheng, C.D. Skinner, J. Taylor, S. Attiya, W.E. Lee, G. Picelli,. And D.J. Harrison, Development of a multichhannel microfluidic analysis system employing afinity capilary electrophoresis for immunoassay. Anal. Chem. 73,1472—1479 (2001). 

Bousse, L., Cohen, C., Nikiforov, T., Chow, A., Kopf-Sill, A.R., Dubrow, R., Parce, J.W., Electrokinetically controlled microfluidic analysis systems. Annu. Rev. Bio-phys. Biomol. Struct. 2000, 29, 155-181. 

Cheng, S.B., Skinner, C.D., Taylor, J., Attiya, S., Lee, W.E., Picelli, G., Harrison, D.J., Development of a multichannel microfluidic analysis system employing affinity capillary electrophoresis for immunoassay. Anal. Chem. 2001, 73(7), 1472-1479. 

At the same time, much simpler yet very successfiil microfluidic analysis systems based on wettable fleeces emerged First very simple dipsticks for e.g. pH measurement based on a single fleece paved the way for more complex test strips that have been sold as lateral-flow tests in the late 1980s [14]. Examples that are still on the market today are test strips for pregnancy [15], drug abuse [16-18], cardiac markers [19] and also upcoming bio-warfare protection [20]. 

Karlinsey, J. M. Advances and Applications of Microfluidic Analysis Systems, University of Virginia, Charlottesville, VA, 2007. 

Sensitive and selective detection techniques are of crucial importance for capillary electrophoresis, microfluidic chips, and other microfluidic analysis systems. Electrochemical detector has attracted considerable interest in these fields owing to its high sensitivity, inherent miniaturization of both the detection and control instrumentation, low cost and power demands, and high compatibility with microfabrication technology. The commonly used electrochemical detection approaches can be classified into three general modes COTiductimetry, potentiometry, and amperometry. 

Electrochemical techniques play a key role in CE, microchip CE, and other microfluidic systems. Future directions of electrochemical techniques will focus on the minimization of the electrochemical detection device and the integration of the electronic circuit and the detection electrodes on microfluidic chips. With the rapid development of microfluidic chips, it is highly desirable to develop new theoretical models, experimental methods, and new experimental devices for the electrochemical detection in microfluidic analysis systems. 

Integrated microfluidic devices Lab-on-a-chip Microfluidic analysis system Miniaturized total analysis system (p-TAS)... 

Lab-on-a-Chip Miniaturized total analysis system (/U-TAS) Microfluidic analysis system Integrated microfluidic devices... 

---