Microflow systems reaction acceleration

Microwave irradiation has been proven useful in accelerating chemical reactions. A unique approach to multicomponent reactions - the combination of microwave irradiation and microreactors - was developed by Organ and Bremner [25]. The three-component coupling reaction of amino pyrazole with an aldehyde and diketone in a glass capillary tube microflow system (1180 pm i.d.) under microwave irradiation (170 W) proceeded smoothly to give the desired quinolinone in high yield (Scheme 4.16). Without microwave irradiation, the reaction efficiency was very low. 

REACTIONS THAT CAN BE ACCELERATED USING MICROFLOW SYSTEMS... 

In this section, we discuss the cases where the use of microflow reactors allows us to conduct reactions under unconventional conditions, such as high temperatures, which significantly accelerate the rates of the reactions. In the macrobatch processes, however, the use of such reaction conditions may cause undesirable side reactions, such as the decomposition or subsequent reactions of products. Precise temperature control and short residence time, which minimize the consecutive side reactions, are responsible for successful reactions in microflow systems. 

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