Microfilaments microfilament-based cytoskeleton

The Locomotion of Amoeba The Locomotion of Fibroblastic Cell Types The Locomotion of Leukocytes The Behavior of Locomoting Cells The Role of the Cytoskeleton in Cell Locomotion The Microtubule-Based Cytoskeleton The Intermediate Filament-Based Cytoskeleton The Microfilament-Based Cytoskeleton The Organization of Microfilaments in Cells Microfilament Dynamics and Cell Locomotion Sites of Lamellar Protrusion May Be Determined by the Nucleation of Actin Polymerization... 

Compounds 338 and 339 have been shown to disrupt microfilament organization and exert profound effects on the morphology of nonmuscle cells without affecting the organization of the microtubular system [256]. Compound 338 was found to affect the polymerization of pure actin in a manner consistent with the formation of a 1 1 complex with G-actin. This phenomenon affected different components of the actin-based cytoskeleton [256]. Comparison to cytochalasin showed 338 to be an order... 

The cytoplasm of eukaryotic cells is traversed by three-dimensional scaffolding structures consisting of filaments (long protein fibers), which together form the cytoskeleton. These filaments are divided into three groups, based on their diameters microfilaments (6-8 nm), intermediate filaments (ca. 10 nm), and microtubules (ca. 25 nm). All of these filaments are polymers assembled from protein components. 

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