Microfabricated Differential Mobility Spectrometer

FIGURE 6.5 Drift tubes for FAIMS or DMS including the configuration commercialized by Thermo Fisher Scientific (a) with a cylindrical shape (with permission from Thermo Fisher Scientific) the first small planar design commercialized by Sionex, Incorporated (b) (from Miller et al., A novel micro-machined high field asymmetric waveform ion mobility spectrometer, Sens. Actuators B 2000 with permission) and the microfabricated, very small structures of the ultraFAlMS (c) manufactured by Owlstone Nanotechnology (from Owlstone White Paper, 2006). 

Compact and simple design allows the cell to be installed without the use of any tools and in less than two minutes. 

Updated version of the traditional curtain plate to accommodate the differential Ion mobility cell. Maintains the same level of robustness and stability associated with the original design. 

FIGURE 6.6 (a) The combination of a DMS with MS commercialized by AB SCIEX with the SelexION technology, which is available as a unit integrated into their lines of mass spectrometers. (Photo courtesy of AB SCIEX.) (b) A photograph of the ultraFAIMS attached to the inlet of a mass spectrometer in recently released technology from Owlstone Nanotech. Both of these designs are intended to separate or filter ions between an electrospray ion source, which often produces a complex mixture of ions from the spray of a liquid sample, and a mass spectrometer. 

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Lamhertus GR et al (2005) Silicon microfabricated column with microfabricated differential mobility spectrometer for GC analysis of volatile organic compounds. Anal Chem 77(23) 7563-7571... 

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