Microcrystalline cellulose moisture content

Bains D, Boutell SL, Newton JM. The influence of moisture content on the preparation of spherical granules of barium sulphate and microcrystalline cellulose. Int J Pharm 1991 69 233-237. 

Alternatively, aw may be measured by isopiestic equilibration. In this method, a dehydrated sorbent (e.g. microcrystalline cellulose) with a known moisture sorption isotherm (section 7.4) is exposed to the atmosphere in contact with the sample in an enclosed vessel. After the sample and sorbent have reached equilibrium, the moisture content of the sorbent can be measured gravimetrically and related to the nw of the sample. 

FIGURE 4.8 Illustration of multiplicative scatter correction (MSC). (a) NIR reflectance spectra of 20 powdered samples of microcrystalline cellulose, (b) Same NIR reflectance spectra after multiplicative scatter correction, revealing differences in moisture content. 

Khan, K.A. Musikabhumma, P. Warr, J.P. The effect of moisture content of microcrystalline cellulose on the compression properties of some formulations. Drug Dev. Ind. Pharm. 1981, 7, 525-538. 

Moisture sorption of microcrystalline cellulose has been studied extensively. Fig. 6A includes the sorption and desorption studies for microcrystalline cellulose. The inserts are plots of moisture content versus time, which approximately represent the kinetics of sorption and desorption at each humidity. The equilibrium adsorption isotherm (Type II) has been fit to the BET equation (C = 16.48, = 0.033 g/g solid) and this curve is... 

The bulk properties of celluloses are generally influenced by adsorbed moisture. The effect of the change in bulk solid properties for microcrystalline cellulose has been demonstrated by a tableting operation in a very simplistic manner. Dry microcrystalline cellulose (%MC = 0.07) was compared with material with a moisture content above that associated with completion of the monolayer (%MC = 5.1). A thermodynamic picture of the character of water in these samples can be based on the adsorbate thermodynamic properties A// > 3.5kcal/mole (14.65 kJ/mole),... 

Nicholas, V. Chambin, O. Andres Rochat-Gonthier, M.-H. Pourcelot, Y. Preformulation effect of moisture content on microcrystalline cellulose (avicel ph-302) and its consequences on packaging performances. Drug Dev. Ind. Pharm. 1999, 25 (10), 1137-1142. 

Microcrystalline cellulose is available from several different sources. These can exhibit a range of tabletting properties, and so the substitution of one brand of microcrystalline cellulose by another must be approached with caution. Microcrystalline cellulose is quite hygroscopic, and its tabletting properties are dependent on its moisture content, with water causing the interparticulate hydrogen bonds to weaken. Therefore, comparisons between different brands must also take the moisture content into account. " ... 

Moisture content typically less than 5% w/w. However, different grades may contain varying amounts of water. Microcrystalline cellulose is hygroscopic. See Table III. 

Cellulose is the structural compound of plant cells and is very common in nature. It is found in plant material usually mixed with other polysaccharides and with lignin, resins, fats, and inorganic substances. However, several vegetal fibers such as cotton or flax contain fairly pure cellulose. Pure cellulose (microcrystalline) obtained by the purification of natural cellulose is also readily available. Although cellulose can be obtained with high purity, the quality of the material may vary depending on the degree of polymerization (DP), moisture content, etc. 

Anderson AH, Newton JM. Influence of moisture content and particle size of barium sulfate on the extrusion properties of mixtures with microcrystalline cellulose. In Carter, R, ed. Rheology of Food. Pharmaceutical and Biological Materials with General Rheology. London Elsevier Applied Science, 1990 25S--67. 

Microcrystalline cellulose (MCC) 5 Moisture content varies with grade hygroscopic... 

If one could conclusively show that there is an effect of plasticizers on reaction rate that is independent of moisture content or a , then this would demonstrate the significance of matrix properties for governing reaction rate. Labuza et al. (1977) studied the Maillard reaction and measured the effects of several parameters. These included temperature, reactant concentration, pH, buffers, and the addition of humectants. The formulation consisted of glucose and casein as reactants within a carrier matrix of microcrystalline cellulose and an inert lipid. Reaction rate was measured both as glucose loss, lysine loss, and pigment production (A42o). 

Figure 9 Force-displacement profiles at various moisture contents of mixtures of microcrystalline cellulose and water (a-d) microcrystalline cellulose-lactose-water (5 5 6) (e) lactose-water (8 2) (f) at a ram speed of 4mm/sec, die diameter of 1.0, and a L/i ratio of 12. Percentage of moisture content of microcrystalline cellulose-water mixture a, 59.4 b, 51.1 d, 45.0. (From Ref. 29.)...

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