Microcoil NMR. Sensitivity and Throughput Issues

Further expansion of the probehead to more coils is also possible, with a concomitant reduction in the total amount of material needed for a kinetic study. 

1000(t2) x 512(ti) data points 16 scans per t increment, 0.256 s acquisition time relaxation delay 3 s (stopped-flow) and 1 s (continuous-flow). Reprinted with permission from Ref. [38]. Copyright (2003) John Wiley Sons. 

The authors wish to acknowledge the support of the National Institutes of Health through grant R01 GM53030 for supporting this research. 

Van Roey 2001, (Crystal structure of a deletion mutant of human thymidylate synthase Delta(7-29) and its ternary complex with Tomudex and dUMP), Protein Sci. 10(5), 988. 

Hutzler, T. S. Tracy 2002, (Atypical kinetic profiles in drug metabolism reactions), Drug Metab. Dispos. 30(4), 355. 

---