Microchip nebulizer

Fig. 13.11. Schematic of (a) the DAPPI setup and (b) photograph of the microchip nebulizer. The small solvent flow is mixed with nitrogen gas and vaporized in the microchip nebuhzer by resistive heating of the platinum wire. The loypton UV lamp irradiates the sample surface that is in contact with the hot reagent gas. Reproduced from Ref. [9] with permission. The American Chemical Society, 2007.

FIGURE 53.3 A microchip-MS interface with a nebulizer that includes an aerodynamic focusing chamber for directing the ESI plume into the mass spectrometer sampling orifice. (Reprinted from Grym, J., et ah. Lab Chip, 6, 1306-1314, 2006. Copyright 2006. With permission from The Royal Society of Chemistry.)... 

Capillary Electrophoresis Chips. Some of the first microchip-CE separations have been performed on glass chips that used on-chip miniaturized pneumatic nebulizers, or on-chip or off-chip liquid junction interfaces coupled to a subatmospheric ESI ion trap instrument. - High-efficiency ( 31,000 plates/chip or 300,000 plates/m) separations on 11 cm long channels, or fast separations on 4.5 cm channels, of peptide/protein samples were achieved (Figure 53.17). Some of these chips were also tested for performing transient isotachophoretic sample preconcentration. ... 

In a recent iimovation (Ostman 2006) the nebulization and evaporation steps, but not the corona discharge and APCI itself, were accomplished on a microchip to provide an efficient low volume interface between GC and APCI-MS. 

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