Microbiological contaminants moulds

In addition, a number of other components will have a marked effect on the susceptibility of polymer dispersions to microbiological contamination. Jakubowski et al. (1992) studied the influence of raw materials on their susceptibility. By adding various of these to water at in-use concentrations, followed by inoculation with a variety of bacteria, yeasts and moulds isolated from contaminated products, they were able to show that many surfactants, defoamers and other additives were highly susceptible (Table 7). 

Microbiological aspects of pharmaceuticals are of importance not only to sterile products but to all products, in that gross contamination should be avoided irrespective of how the product is used or administered. Although bacteria, moulds and yeasts constitute the major sources of contamination, pyrogens are also included under this heading. 

Polyene antibiotics are used extensively to control fungal contamination, mainly yeasts and moulds, in microbiological medium, in biological samples from which it is hoped to isolate bacteria, and especially in cell and tissue culture media [551—559]. Polyenes are used in conjunction with benzyl penicillin and streptomycin to suppress microbial contaminants in tissue cultures. 

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