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Microbial hydroxylation ketones

From the study of a microbially mediated oxidation of arteether 28b, sufficient quantities of 7a-hydroxy 180 and 15-hydroxy derivatives 182 were obtained to employ them as intermediates for the preparation of fluorinated compounds. The hydroxyl groups were oxidized to the corresponding aldehyde 187, or ketone 188, with catalytic quantities of tetra- -propylammonium perruthenate (TPAP) in the presence of excess iV-methylmorpholine A -oxide. On reaction with DAST, 187 and 188 were converted into the corresponding geminal difluoro derivatives, 189 (63%) and 190 (42%). In addition to 190, a monofluoro olefin 191 was obtained in 25% yield from 188 on reaction with DAST <1995JME4120>. [Pg.880]

See other pages where Microbial hydroxylation ketones is mentioned: [Pg.158]    [Pg.158]    [Pg.158]    [Pg.240]    [Pg.251]    [Pg.430]    [Pg.51]    [Pg.400]    [Pg.448]    [Pg.51]    [Pg.53]    [Pg.66]    [Pg.66]    [Pg.433]    [Pg.222]    [Pg.263]    [Pg.1066]    [Pg.1086]    [Pg.263]    [Pg.430]    [Pg.433]    [Pg.15]    [Pg.227]    [Pg.45]    [Pg.49]    [Pg.66]    [Pg.52]    [Pg.67]    [Pg.327]    [Pg.323]    [Pg.110]   
See also in sourсe #XX -- [ Pg.158 ]

See also in sourсe #XX -- [ Pg.158 ]

See also in sourсe #XX -- [ Pg.7 , Pg.158 ]

See also in sourсe #XX -- [ Pg.7 , Pg.158 ]

See also in sourсe #XX -- [ Pg.158 ]



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Hydroxylation ketones

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