Micellar nanocontainers

Savic R, Luo LB, Eisenberg A, May singer D (2003) Micellar nanocontainers distribute to defined cytoplasmic organelles. Science 300 615-618. 

Kabanov AV, Alakhov V. Pluronic block copolymers in drug delivery from micellar nanocontainers to biological response modifiers. Crt Rev Ther Drug Target 2002 19 1-73. 

Kabanov, A. V. Alkhov, V. Yu. (2002). Plmonic block copolymers in drug deliveiy From micellar nanocontainers to biological response modifiers. Critical Rev Therap Drug Carrier Syst, 19, 1-72. 

Whenever block copolymers are dissolved in a selective solvent that is a thermodynamical good solvent for one block and a precipitant for the other, the copolymer chains may associate reversibly to form micellar aggregates in deep analogy with the situation observed for classical low-MW surfactants, hi this respect, a CMC can be defined and experimentally measured for block copolymer micelles, as discussed in Sect. 2.1. Compared to low-MW surfactants, the values of the CMC are much lower in the case of block copolymer macrosurfactants. This motivates, e.g., the use of block copolymer micelles as nanocontainers for drug dehvery. In contrast to low-MW surfactants, these block copolymer nano containers do not dissociate into unimers whenever they are diluted in the blood stream and can therefore transport the drugs to a specifically targeted area provided that they are functionalized by suitable mo cities for site-recognition [3]. Nevertheless, macromolecular chains can encounter some dissolution problems whenever they are placed in a se-... 

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