Sulfinpyrazone Metoprolol

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The antihypertensive effects of oxprenolol can be reduced or abolished by sulfinpyrazone. The pharmacokinetics of metoprolol are not affected by sulfinpyrazone. 

A study in 9 healthy subjects found that sulfinpyrazone 4(X) mg twice daily did not affect the pharmacokinetics of metoprolol 1(X) mg twice daily. No adverse effects were noted in healthy subjects during concurrent... 

Information seems to be limited. If sulfinpyrazone is given to patients taking oxprenolol for hypertension, the effects should be monitored. It seems likely that this interaetion eould be aeeommodated by raising the dosage of the oxprenolol but this needs eonfirmation. The effect of this interaction on cardiac workload appears to be less important, but it would still be prudent to monitor coneurrent use if oxprenolol is used for angina. Metoprolol may be a suitable alternative to oxprenolol as it does not appear to interact with sulfinpyrazone. 

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