Metoclopramide antiemetic action

Because of their potent antiemetic action, metoclopramide and domperidone are used for the prevention and treatment of emesis. 

Substituted benzamides include metoclopramide and trimethobenzamide. Their primary mechanism of antiemetic action is believed to be dopamine-receptor blockade. Trimethobenzamide... 

Antihistamines, dronabinol, glucocorticoids, and metoclopramide have antiemetic actions that are useful in the management of vomiting caused by anticancer drugs. Levodopa causes nausea because it is converted to dopamine, which activates dopamine receptors in the emetic center. The answer is (C). 

Metoclopramide (Region, Clopro, Octamide) [Antiemetic/ Dopamine Antagonist] Uses Tx NA Action T UGI motility, blocks dopamine in chemoreceptor trigger zone Dose Adults. 10 mg IV, 10-20 mg IM Peds. 1-2 mg/kg IV/IM Caution [B, -] Drugs w/ extrapyramidal ADRs Contra ... 

Phenothiazines such as prochlorperazine, thiethylperazine, and chlorpromazine see Chapter 18) are among the most commonly used antinauseants and antiemetics. Their principal mechanism of action is dopamine receptor antagonism at the CTZ. Compared to metoclopramide or ondansetron see above), these drugs do not appear to be as uniformly effective in cancer chemotherapy-induced emesis. On the other hand, they also possess antihistaminic and anticholinergic activities, which are of value in other forms of nausea, such as motion sickness. 

NSAIDs ANTIEMETICS 1. Metoclopramide speeds up the onset of action of tolfenamic acid 2. Metoclopramide i efficacy of ketoprofen Metoclopramide promotes gastric emptying 1. Tolfenamic acid reaches its main site of absorption in the small intestine more rapidly 2. Ketoprofen has low solubility and has less time to dissolve in the stomach therefore less ketoprofen is absorbed 1. This interaction can be used beneficially to hasten the onset of analgesia 2. Take ketoprofen at least 2 hours before metoclopramide... 

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