1-Methyluracil, platinum complex

The work by Lippard and coworkers [2][24][25][88][95][98-100] derives its chief motivation from the understanding of the interaction between the anticancer drug cA-[PtCl2(NH3)2] and pyrimidine nucleobases. Unfortunately, the reaction of c7v-[PtCl2(NH3)2] with molecules such as uracil or thymine leads to non-crystalline dark blue materials ( platinum blues ) which are difficult to characterize. The use of a ligand with similar but more restricted number of donor sites, such as a-pyridone (hp), allowed isolation and full characterization of relevant platinum complexes. Related work has used 1-methyluracil (1-Me-urac) and 1-methylthymine (1-Me-thym) in which one of the pyrimidine nitrogens has been blocked [101]. 

Lippert and co-workers have reported a similar series of A-,O-bridged platinum(III) dimers in which the bridging ligands are the pyrimidines, 1-methyluracil, 1-methylthymine, or 1-ethylthy-mine. Chemical oxidation of dimeric platinum(II) complexes gave [Pt2XY(L)2(NH3)4]2+, X,Y = N03", N02, H20, Cl", or Br", L=l-MeU, 1-MeT, 1-EtT. 27 t30 They too found that the HT dimers are more stable than the HH.430... 

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