Methylprednisolone stents

Inflammatory response after stent implantation plays an important role in the cascade of neointimal formation. A positive correlation between inflammatory reaction and restenosis has been observed (16). Perivasculitis caused by stent deployment also participates in the neointimal formation (17). Corticosteroids, as an anti-inflammatory agent, have been evaluated. Methylprednisolone (MP)-loaded stents with different doses showed a positive dose-related effect on neointimal hyperplasia (18). Furthermore, MP-coated stents showed decreased macrophages at the stented sites (19). In clinic, dexamethasone-coated stents showed an inhibitive effect on neointimal hyperplasia in selected patients (20), although no beneficial effect was observed in a randomized trial compared to bare stents (21). For other type of drugs with anti-inflammatory characteristics, such as ibuprofen, colchicine, aton/astatin, and probucol, no favorable effects on neointimal hyperplasia were observed (18,22,23). 

Abbreviations CEL, cellulose DXM, dexamethasone EIPA, ethylisopropylamiloride FIB, fibrin MR methylprednisolone NA, not available Neo-R, neointima reduction PC, phosphorylcholine PCL, polycaprolactone PFM-P75, polyfluoroalkoxyphosphazene PLLA(PLA), poly-L-lactic acid POP, polyorganophosphazene PU, polyurethane Q-DL, Quanam drug eluting stent Q-M, Quanam metal stent SNR sodium nitroprusside TIMP, tissue inhibitors of metalloproteinase. 

I 19 Huang Y Liu X, Wang L, et al. Local methylprednisolone delivery using a BiodivYsio phosphorylcholine-coated drug-delivery stent reduces inflammation and neointimal hyperplasia in a porcine coronary stent model, Int J Cardiovasc Intervent 2003 5(3) I 66-171. 

Wang L, Salu K, Verbeken E, et al. Stent-mediated methylprednisolone delivery reduces macrophage contents and in-stent neointimal formation. Coron Artery Dis 2005 ... 

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