Methylphenidate pharmacokinetics

Birmaher, B.B., Greenhill, L., Cooper, T., Fried, J., and Maminski, B. (1989) Sustained release methylphenidate pharmacokinetic studies in ADDH males. ] Am Acad Child Adolesc Psychiatry 28 768-772. [Pg.261]

Modi NB, Wang B, Noveck RJ, et al Dose-proportional and stereospecific pharmacokinetics of methylphenidate delivered using an osmotic, controlled-release oral delivery system. J Clin Pharmacol 40 1141-1149, 2000h... [Pg.197]

Strattera (package insert). Indianapolis, IN, Eli Lilly and Co, 2005 Swanson JM, Volkow ND Pharmacokinetic and pharmacodynamic properties of stimulants implications for the design of new treatments for ADHD. Behav Brain Res 130 73-78, 2002 Swanson J, Gupta S, Lam A, et al Development of a new once-daily formulation of methylphenidate for the treatment of attention-deficit/hyperac-tivity disorder proof of concept and proof of product studies. Arch Gen Psychiatry 60 204-211, 2003... [Pg.199]

Volkow ND, Ding U, Fowler JS, Wang GJ, Logan J, Gatley JS, Dewey SL, Ashby C, Lieberman J, Hitzemann R, Wolf AP (1995) Is methylphenidate like cocaine Studies on their pharmacokinetics and distribution in human brain. Arch Gen Psychiatry 52 456 463. [Pg.392]

KImko HC, Cross JT, Abemethy DR. Pharmacokinetics and clinical effectiveness of methylphenidate. Clin Pharmacokinet f 999 37 457-70. [Pg.126]

An example from our own laboratory is the methylphenidate bioanalyti-cal chiral LC-MS/MS assay in support of toxicokinetics (TK) and PK studies (vide infra). Attention-deflcit hyperactivity disorder (ADHD) is a recognized medical problem characterized by symptoms of inattention, hyperactivity, and impulsivity. Methylphenidate (MPH Ritalin methyl-alpha-phenyl-2-piperid-inacetate hydrochloride) is prescribed for the treatment of ADHD. MPH has two chiral centers yielding enantiomers with distinct pharmacokinetic and pharmacodynamic properties in humans. It is known that the t/-threo [2R,2 R]-MPH (i.e., (-i-)-threo) exhibits greater pharmacological activity than the... [Pg.625]

DeVane CL, Markowitz JS, Carson SW, Boulton DW, Gill HS, Nahas Z, Risch SC. Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabo-lizers. J Clin Psychopharmacol 2000 20(3) 347-9. [Pg.2312]

Lewis BR, Aoun SL, Bernstein GA, Crow SJ. Pharmacokinetic interactions between cyclosporine and bupropion or methylphenidate. J Child Adolesc Psychopharmacol 2001 ll(2) 193-8. [Pg.2312]

Example Methylphenidate HC1 (Ritalin, Concerta) CSS II Route PO, IV Pregnancy category C Pharmacokinetic Incompletely absorbed from GI tract metabolized in liver excreted in urine and feces via biliary system... [Pg.195]

Methylphenidate Metabolism. The metabolism and pharmacokinetics of methylphenidate have been studied extensively. Methylphenidate (8)is administered as the racemic threo isomer, but the (-)-threo enantiomer is more rapidly metabolized. [Pg.177]

Srinivas, N.R. Hubbard, J.W. Korchinski, E.D. Midha, K.K. Enantiose-lective pharmacokinetics of dl-threo-methylphenidate in humans. Pharm. Res. 1993, 10, 14-21. [Pg.279]

No pharmacokinetic interaction appears to occur between modafinil and methylphenidate. [Pg.204]

Two children taking valproic acid rapidly developed severe dyskinesias and bruxism after the first and second dose of methylphenidate, respectively. Valproate appears to potentiate the effects of methylphenidate, possibly by a pharmacokinetic mechanism, or because of additive dopaminergic effects. The authors of the re-... [Pg.578]

Methylphenidate can increase the levels and rate of response to tricyclic antidepressants. This has led to both increased beneficial and adverse effects. No significant pharmacokinetic interaction has been reported between desipramine and dexamfetamine or methylphenidate. An isolated report describes a blood dyscrasia in a child given methylphenidate and imipramine. [Pg.1230]

In contrast, a retrospective review in 142 children and adolescents taking either desipramine alone, or desipramine with dexamfetamine or methylphenidate, indicated the absence of a clinically significant interaction between desipramine and either stimulant. Pharmacokinetic parameters were similar in each group. ... [Pg.1230]

Hammerness P, Georgiopoulos A, Doyle RL, Utzinger L, Schillinger M, Martelon M, Brodziak K, Biederman J, Wilens TE. An open study of adjunct OROS-methylphenidate in children who are atomoxetine partial responders II. Tolerability and pharmacokinetics. J Child Adolesc Psychopharmacol 2009 19(5) 493-9. [Pg.21]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...