Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Methylnaltrexone

Methylnaltrexone was launched in 2008 for the treatment of OIC in patients with advanced illness receiving palliative care, when response to laxative therapy has not been sufficient. Due to its poor oral bioavailability, 4 is administered subcutaneously every other day. Approximately 50% of the drug is excreted in the urine and feces with 85% eliminated unchanged [30]. [Pg.148]

Guay DRP (2009) Methylnaltrexone methobromide The first peripherally active, centrally inactive opioid receptor-antagonist. Consult Pharm 24 210-226. [Pg.151]

Slatkin N, Thomas J, Lipman AG Wilson G Boatwright ML, Wellman C, Zhnkovsky DS, Stephenson R, Portenoy R, Stambler N, Israel R. (2009) Methylnaltrexone for treatment of opioidinduced constipation in advanced illness patients. J Support Oncol 7 39 6. [Pg.151]

Reichle FM, Conzen PF. (2008) Methylnaltrexone, a new peripheral J,-receptor antagonist for the prevention and treatment of opioid-induced extracerebral side effects. Curr Opin Invest Drugs 9 90-100. [Pg.151]

Yuan CS. (2007) Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects. Ann Pharmacother 41 984-993. [Pg.151]

Yuan CS, Foss JF, Moss J. (1995) Effects of methylnaltrexone on morphine-induced inhibition of contraction in isolated guinea-pig ileum and human intestine. Eur J Pharmacol 276 107-111. [Pg.151]

Yuan CS, Foss JF. (2000) Oral methylnaltrexone for opioid-induced constipation. JAm Med Assoc (JAMA) 284 1383-1384. [Pg.151]

Foss JF, Bass AS, Goldberg LI. (1993) Dose-related antagonism of the emetic effect of morphine by methylnaltrexone in dogs. J Clin Pharmacol 33 747-751. [Pg.152]

Alvimopan, methylnaltrexone bromide Potent antagonists with poor entry into the central nervous system can be used to treat severe opioid-induced constipation without precipitating an abstinence syndrome ... [Pg.705]

Opioid receptor antagonists Alvimopan, methylnaltrexone block intestinal ii-opioid receptors but do not enter CNS, so analgesia is maintained... [Pg.1331]

Oral 400, 800 mg/5 mL aqueous suspension Methylnaltrexone bromide (Relistor)... [Pg.1336]

Thomas 3 et al Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl 3 Med 2008 358 2332. [PMID 18509120]... [Pg.1337]

A solution of 3-methylnaltrexone (0.48 g, 1.35 mmol) in methylene chloride (30 ml) was cooled with an ice-water bath, and then added a solution of boron tribromide (5.4 ml, 1 M solution in methylene chloride, 5.4 mmol). The reaction mixture was stirred at rt. for 15 hr, basified with NH4OH, and extracted with methylene chloride (60 ml). The extract was washed with water (2 times 15 ml), dried over anhydrous sodium sulfate, and evaporated in vacuo to dryness to give naltrexone (0.45 g, 98% yield). [Pg.2395]

In a randomized, double-bhnd, placebo-controlled trial of the efficacy of intravenous methylnaltrexone (0.015-0.095 mg/kg) in treating chronic methadone-induced constipation in 22 patients attending a methadone maintenance program (oral methadone linctus 30-100 mg/day), methylnaltrexone induced immediate bowel movements in all subjects (32). There were no opioid withdrawal symptoms or significant adverse effects. [Pg.580]

Yuan CS, Foss JF, O Connor M, Osinski J, Karrison T, Moss J, Roizen MF. Methylnaltrexone for reversal of constipation due to chronic methadone use a randomized controlled trial. JAMA 2000 283(3) 367-72. [Pg.585]

The 17 - N- a 11 y I - (n a I o x o n e. 3a) and 17 - /V-c v c lop I opv I m e t h v I (naltrexone, 3b) analogues of oxymorphone (2d) are the prototype opioid receptor antagonists with some selectivity for MOR. They have entered clinical practice as treatments for narcotic overdose (naloxone) and alcoholism or opioid abuse/dependence (naltrexone). The 17-quatemary derivative of naltrexone, methylnaltrexone (4) has recently been introduced into clinical practice as a treatment for opiate-induced bowel dysfunction [1],... [Pg.95]


See other pages where Methylnaltrexone is mentioned: [Pg.148]    [Pg.148]    [Pg.592]    [Pg.620]    [Pg.175]    [Pg.51]    [Pg.51]    [Pg.52]    [Pg.52]    [Pg.152]    [Pg.704]    [Pg.708]    [Pg.1320]    [Pg.2394]    [Pg.2394]    [Pg.2394]    [Pg.323]    [Pg.326]    [Pg.337]    [Pg.338]    [Pg.365]    [Pg.32]    [Pg.32]    [Pg.32]    [Pg.66]    [Pg.94]    [Pg.66]   
See also in sourсe #XX -- [ Pg.51 ]

See also in sourсe #XX -- [ Pg.324 , Pg.326 ]

See also in sourсe #XX -- [ Pg.420 ]

See also in sourсe #XX -- [ Pg.227 ]




SEARCH



Methylnaltrexone bromide

Methylnaltrexone bromide (RELISTOR

© 2024 chempedia.info