Transplantation methylmalonic acidemia

Lubrano R, et al. Kidney transplantation in a girl with methylmalonic acidemia and end stage renal failure. Pediatr Nephrol. 2001 16(11) 848-51. 

Lubrano R, et al. Renal transplant in methylmalonic acidemia could it be the best option Report on a case at 10 years and review of the literature. Pediatr Nephrol. 2007 22(8) 1209-14. 

Cheikrapemi A, et d. Metabolic stroke in methylmalonic acidemia five years after liver transplantation. J Pediatr. 2002 140(2) 261-3. 

Lubrano R, et al. Pregnancy in a methylmalonic acidemia patient with kidney transplantation a case report. Am J Transplant 2013 13(7) 1918-22. 

Methylmalonic acidemia is an inborn error of metabolism leading to renal tubular dysfunction and to progressive renal failure in many cases. Renal disease seems to be caused by toxic products of metabolism and can be ameliorated by good metabolic control. Renal US is not specific. Further imaging maybe required according to chronic renal failure or after transplantation, as combined liver-kidney transplantation is a promising therapeutic option (also see Chap. 21) (van t Hoff et al. 1999). 

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