Methylidene malonates

Methylidene malonates are other monomers that give biodegradable polymers and polymerize according to a similar mechanism than alkylcyanoacrylates. 

Micellization of polydiene copolymers was examined by Petrak and co-workers [ 165] in the case of PEO-PI-PEO for the development of controlled drug release systems. This interest in biomedical applications was also the starting point for extensive studies on micellar systems obtained with PEO-poly(amino acid) [166, 167], PEO-polyesters block copolymers [168, 169] and PEO-poly (ethylacrylate) [170]. PEO-poly(methylidene malonate), also designated by PEO-PMM 212, of the following structure were developed in our group ... 

Bru-Magniez, N., Larras, V., Riess, G., Breton, R, Couvreur, P. and Roques-Carmes, C. (1998) Novel surfactant copolymers based on methylidene malonate. French Patent 9,801,001, January 29,1998. Couvreur, P. (1988) Poly(alkylcyanoacrylates) as colloidal drug carriers. Crit. Rev. Ther. Drug... 

Studer, R, Limal, D., Breton, R and Riess, G. (2005) Synthesis and characterization ofpoly(eth-ylene oxide)-block-poly(methylidene malonate 2.1.2) block copolymers bearing a mannose group at the PEO chain end. Bioconj. Chem., 16,223-229. 

---